Basic information:
Product name:DSIP
CAS: 62568-57-4
MF: C35H48N10O15
MW: 848.8136
Type:Finished vials
Specification:2mg/vial,5mg/vial,10mg/vial.
Appearance:White frozen dry powder/lyophilized powder

Introduction:
Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.

Delta sleep-inducing peptide isolated it from the cerebral venous blood of rabbits in an induced state of sleep. It was primarily believed to be involved in sleep regulation due to its apparent ability to induce slow-wave sleep in rabbits, but studies on the subject have been contradictory.


DSIP is an amphiphilic peptide of molecular weight 850 daltons with the amino acid motif:
N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C

It has been found in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids. In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). It is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon.

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