Quick detail:
Product Name: SR9011
CAS: 1379686-29-9
MF:  C23H31ClN4O3S
MW:  479.03524
Type:  Analysis reagent
Grade:  Medicine Grade
Standard:  USP
Apprarance:  White powder

Application:
SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB-α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism.

Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure.

Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic

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Q1:Can I get some samples?
A:Sure,we can supply the free sample,but the shipping cost be paid buy our customers.
 
Q2:How to make orders?
A:Please send inquiry to us,after we come to an agreement,send payment via Western Union,Moneygram or Bank account,then we ship products out and give tracking number to you.
 
Q3:How to delivery?
A:Pack shipped in 3 days(Chinese holiday not included) after payment,usually ship via EMS,HKEMS,DHL,TNT,FedEx,UPS...
If there any troubles with shipping address,we will ship with specail safe and hidden packages,to guarantee you get packs without problems.
 
Q4:Is there any discount?
A:Yes.The price is negotiable,If you order large quantity or some products together,you will get discount.
 
Q5:What is the Minimum order quantity?
A:The Min. order quantity according to your request,10g,50g all is OK.
But the price according to the order quantity,the larger the order is,the better the price is.
 
Q6:How to handle quality complaints?
A:Our quality control will reduce the quality to near zero,but if there is a quality problem caused by us,we will ship free products for replacement or refund your loss.


1. Top quality and factory price,a discount would be given when you make a large order.
2. Rich experienced in delivering,package will be reshipped if sent failed.
3. Enough stock ensure the prompt delivery time.
4. Good after-sales service,any of your question would be solved for the first as soon as possible.
5. Adhering to the principle of customer first conviction,we will provide the best and the most sincere services as possible as we can.